Methanol → HCID 21015966, compound

HRID 1743744Notes

Reaction equation

HRID 1743744 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:8][C:7]([CH3:10])([CH3:9])[CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH3:22]O>>[CH3:22][O:5][C:3](=[O:4])[C@@H:2]1[CH2:6][C:7]([CH3:10])([CH3:9])[CH2:8][NH:1]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 250673061-(tert-Butoxycarbonyl)-4,4-dimethyl-L-proline

Product 1

HCID 21015966HCID 21015966, compound

Procedure

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Workup

  1. concentrationThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Sources & evidence

ORD record
ord-b1b96c8f1f204e7c84298cd80dfe5f43
Source dataset
uspto-grants-2006_03
Patent number
US07012066B2

Reaction notes

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