HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 21015966, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4,4-dimethyl-L-proline | HCID 25067306 | — |
| Product | HCID 21015966 | HCID 21015966 | — |
Reaction Steps
To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012066B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-b1b96c8f1f204e7c84298cd80dfe5f43 |
| Source note | uspto-grants-2006_03 |