Hydrochloric Acid → HCID 178483646, compound

Participants

Reaction Steps

A solution of 1.45 g (5.34 mmol) of trans-[2-(4-hydroxymethyl-cyclohexyl)-ethyl]-methyl-carbamic acid tert-butyl ester in 10 ml dioxane was treated at 10° C. with 13.4 ml (53.4 mmol) of HCl in dioxane (4M). After 3.5 h at RT, the reaction was evaporated to give 1.6 g (quantitative) of trans-[4-(2-Methylamino-ethyl)-cyclohexyl]-methanol hydrochloride, MS: 172 (MH+).

Provenance & Evidence