Hydrochloric Acid → HCID 178483646, compound

HRID 1743789Notes

Reaction equation

HRID 1743789 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([CH2:17][OH:18])[CH2:13][CH2:12]1)C)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:6][NH:7][CH2:9][CH2:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([CH2:17][OH:18])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178483648HCID 178483648, compound

Product 1

HCID 178483646HCID 178483646, compoundYield 144.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 1.45 g (5.34 mmol) of trans-[2-(4-hydroxymethyl-cyclohexyl)-ethyl]-methyl-carbamic acid tert-butyl ester in 10 ml dioxane was treated at 10° C. with 13.4 ml (53.4 mmol) of HCl in dioxane (4M). After 3.5 h at RT, the reaction was evaporated to give 1.6 g (quantitative) of trans-[4-(2-Methylamino-ethyl)-cyclohexyl]-methanol hydrochloride, MS: 172 (MH+).

Workup

  1. customthe reaction was evaporated

Sources & evidence

ORD record
ord-d7be2ce2c07f40978f75a330cb475f40
Source dataset
uspto-grants-2006_03
Patent number
US07012077B2

Reaction notes

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