Acetic Anhydride → HCID 69662429, compound

HRID 1743805Notes

Reaction equation

HRID 1743805 reaction equation
[CH3:1][C:2]1[C:3]([CH2:12][CH:13]=[CH2:14])=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].C(N(CC)CC)C.[C:22](OC(=O)C)(=[O:24])[CH3:23]>ClCCl>[CH3:1][C:2]1[C:3]([CH2:12][CH:13]=[CH2:14])=[C:4]([O:11][C:22](=[O:24])[CH3:23])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 22236609HCID 22236609, compound

Product 1

HCID 69662429HCID 69662429, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-methyl-4-nitro-2-(2-propenyl)-phenol (5.19 g, 26.9 mmol) in dichloromethane (200 ml) at 0° was added triethylamine (5.43 g, 53.8 mmol) and acetic anhydride (3.29 g, 32.3 mmol). After 30 min, the reaction mixture was evaporated to a residue which was purified by chromatography (silica, 2% to 10% ethyl acetate in hexane) to give an orange oil (4.80 g, 76%).

Workup

  1. customthe reaction mixture was evaporated to a residue which
  2. customwas purified by chromatography (silica, 2% to 10% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-7c8b182e88464f95abbf6519082f23e0
Source dataset
uspto-grants-2006_03
Patent number
US07012090B1

Reaction notes

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