反应详情

温度

40 °C

A mixture of N,N-dibenzyl-N-(piperidin-4-ylmethyl)amine (EXAMPLE 4, Step 3, 3.3 g, 11.21 mmol) and 2,2-dimethyloxirane (12.1 mL, 134.5 mmol) in methanol (40 mL) and tetrahydrofuran (5 mL) was heated at 40° C. with stirring for 17 h. The volatile components were removed and the residue was purified by flash column chromatography on amine gel eluting with hexane/ethyl acetate (50:1) to afford 3.0 g (73%) of the title compound as a colorless amorphous.

1. customThe volatile components were removed
2. customthe residue was purified by flash column chromatography on amine gel
3. washeluting with hexane/ethyl acetate (50:1)