{[1-(3-Methoxy-2,2-dimethylpropyl)piperidin-4-yl]methyl}amine → 5-amino-6-chloro-N-{[1-(3-methoxy-2,2-dimethylpropyl)piperidin-4-yl]methyl}2-methyl-imidazo[1,2-a]pyridine-8-carboxamide

HRID 1743826Notes

Reaction equation

HRID 1743826 reaction equation
C[C:2]1[N:6]2[C:7]([NH2:15])=[C:8]([Cl:14])[CH:9]=[C:10]([C:11]([OH:13])=O)[C:5]2=[N:4][C:3]=1[CH3:16].[CH3:17][O:18][CH2:19][C:20]([CH3:31])([CH3:30])[CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][NH2:29])[CH2:24][CH2:23]1>>[NH2:15][C:7]1[N:6]2[CH:2]=[C:3]([CH3:16])[N:4]=[C:5]2[C:10]([C:11]([NH:29][CH2:28][CH:25]2[CH2:24][CH2:23][N:22]([CH2:21][C:20]([CH3:31])([CH3:30])[CH2:19][O:18][CH3:17])[CH2:27][CH2:26]2)=[O:13])=[CH:9][C:8]=1[Cl:14]

Participants

3

Reactant 2

HCID 22236505{[1-(3-Methoxy-2,2-dimethylpropyl)piperidin-4-yl]methyl}amineHCID 67550158Methyl 5-amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxylic acid

Product 1

HCID 222365015-amino-6-chloro-N-{[1-(3-methoxy-2,2-dimethylpropyl)piperidin-4-yl]methyl}2-methyl-imidazo[1,2-a]pyridine-8-carboxamide

Procedure

The title compound was prepared according to the procedure described in the Step 6 in EXAMPLE 1 from 5-amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxylic acid (EXAMPLE 1, Step 5) and {[1-(3-methoxy-2,2-dimethylpropyl)piperidin-4-yl]methyl}amine (EXAMPLE 9, Step 1).

Sources & evidence

ORD record
ord-6f2cc9301c5c450d8dcbbfdf5e48aba9
Source dataset
uspto-grants-2006_03
Patent number
US07012080B2

Reaction notes

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