Sodium Bicarbonate → HCID 22236586, compound

To a solution of 9-chloro-4-methyl-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocine (6.0 g, 0.023 mole approximately) in hydrochloric acid (1 N, 200 mL) cooled to 0° C. was added sodium nitrite (4.0 g, 0.058 mole) in water (20 mL). The mixture was stirred for 1 hour and treated with sodium bicarbonate, extracted with ethyl acetate (3×100 mL). The combined organic layers were washed with saturated sodium chloride (200 mL), dried and concentrated to a light brown oil. The oil was redissolved in THF (50 mL) and added to a suspension of lithium aluminum hydride (4.0 g, 0.10 mole) in THF (100 mL) and the mixture refluxed for 3 hours. The excess hydride was destroyed at 0° C. by the cautious addition of ethyl acetate. The mixture was washed with aqueous potassium sodium tartrate (10% v/w, 200 mL) and saturated aqueous sodium chloride (150 mL), dried (sodium sulfate) and concentrated. Evaporation in vacuo provided 4.9 g of the title compound as a light yellow oil. This oil was used for indole formation without further purification. 1H NMR (CDCl3): 7.25 δ (s, 1H); 7.00 δ (d, 2H); 3.00 δ (m, 2H); 2.90 δ (m, 2H); 2.78 δ (m, 2H); 2.40 δ (s, 3H); 2.30 δ (t, 2H).

1. extractionextracted with ethyl acetate (3×100 mL)
2. washThe combined organic layers were washed with saturated sodium chloride (200 mL)
3. customdried
4. concentrationconcentrated to a light brown oil
5. dissolutionThe oil was redissolved in THF (50 mL)
6. temperaturethe mixture refluxed for 3 hours
7. customThe excess hydride was destroyed at 0° C. by the cautious addition of ethyl acetate
8. washThe mixture was washed with aqueous potassium sodium tartrate (10% v/w, 200 mL) and saturated aqueous sodium chloride (150 mL)
9. dry with materialdried (sodium sulfate)
10. concentrationconcentrated
11. customEvaporation in vacuo

ORD record

ord-1e5e7ec1a2374ad480fdac2ac0106479

Source dataset

uspto-grants-2006_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07012089B2