HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 9824215, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Reactant | 3-(Trifluoromethyl)benzyl chloride | HCID 69716 | — |
| Reactant | 1-Pyrrolidino-1-cyclohexene | HCID 70768 | — |
| Reactant | HCID 17958777 | HCID 17958777 | — |
| Product | HCID 9824215 | HCID 9824215 | — |
Reaction Steps
In the manner described for Example 6, 2-(dimethylaminothiophen-3-ylmethyl)cyclohexanone was first prepared from dimethylamine hydrochloride, thiophene-3-carbaldehyde and 1-(pyrrolidino)-1-cyclohexene and then, by reaction with 3-chloromethyl benzotrifluoride in a Grignard reaction and subsequent precipitation of the hydrochloride, 2-(dimethylaminothiophen-3-ylmethyl)-1-(3-trifluoromethylbenzyl)cyclohexanol hydrochloride was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012099B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-a87e939221464eb5a937eaf53dcf5e81 |
| Source note | uspto-grants-2006_03 |