反应详情

A mixture of 7-benzyloxy-6-bromo-4-chloro-2-methyl-quinoline (10.0 g, 27.6 mmol) and pyrrolidine (47 mL, 0.562 mol) was refluxed during 3 h. The mixture was cooled down and the pyrrolidine was evaporated under high vacuum. The residue was taken up in dichloromethane, washed with water and brine, dried over sodium sulfate, filtered and the solvents were evaporated under vacuum. 6.9 g of the title compound were obtained. Brown solid, ISP-MS: m/e=399.2 ([M+H]+).

1. temperaturewas refluxed during 3 h
2. temperatureThe mixture was cooled down
3. customthe pyrrolidine was evaporated under high vacuum
4. washwashed with water and brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customthe solvents were evaporated under vacuum