Ketoprofen → 2-Phenylpropionic acid

HRID 1743980Notes

Reaction equation

HRID 1743980 reaction equation
[OH:1][C:2]([CH:4]([C:6]1[CH:19]=[CH:18][CH:17]=[C:8](C(C2C=CC=CC=2)=O)[CH:7]=1)[CH3:5])=[O:3]>C1COCC1>[C:6]1([CH:4]([CH3:5])[C:2]([OH:3])=[O:1])[CH:19]=[CH:18][CH:17]=[CH:8][CH:7]=1

Participants

3

Reactant 1

HCID 3825Ketoprofen

Product 1

HCID 102962-Phenylpropionic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Working as in Example 35, with 0.389 g of phase, 0.18 g of LiOH monohydrate, 60 ml of THF and hydrolysis for 48 h, 0.31 g of α-phenylpropionic acid and ketoprofen is obtained.

Sources & evidence

ORD record
ord-108e6fa816294ee9959dd583a6c4a825
Source dataset
uspto-grants-2006_03
Patent number
US07012138B1

Reaction notes

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