Formamide → N-((2,4-Difluorophenyl)(tosyl)methyl)formamide

Temperatur

50 °C

To 2,4-difluorobenzaldehyde (1.42 g, 10.0 mmol) is added toluene (5.0 mL), acetonitrile (5.0 mL), formamide (0.993 mL, 25.0 mmol) and chlorotrimethylsilane (1.40 mL, 11.0 mmol) in order. The cloudy mixture is heated to 50° C. and stirred at this temperature for 7 hours. p-Toluenesulfinic acid (2.19 g, 14.0 mmol) is added, and the mixture stirred at 50° C. for 6 hours, then for 3 hours at room temperature. MTBE (18.0 mL) and water (17.0 mL) are added, and the mixture stirred at room temperature for 15 minutes. The layers are separated, and the aqueous layer extracted with MTBE (5.0 mL). Most of the solvents are removed from the combined organic extracts leaving a white semi-solid. To the residual is added hexane (10.0 mL) and water (10.0 mL), and the resulting slurry stirred at room temperature for 30 minutes, then filtered. The cake is washed with hexane (2×) and dried in a vacuum-oven (30° C.) for 18 hours. The title compound may be obtained as a white powder (2.58 g, 79%).

1. stirringthe mixture stirred at 50° C. for 6 hours
2. waitfor 3 hours at room temperature
3. stirringthe mixture stirred at room temperature for 15 minutes
4. customThe layers are separated
5. extractionthe aqueous layer extracted with MTBE (5.0 mL)
6. customMost of the solvents are removed from the combined organic extracts
7. customleaving a white semi-solid
8. stirringthe resulting slurry stirred at room temperature for 30 minutes
9. filtrationfiltered
10. washThe cake is washed with hexane (2×)
11. customdried in a vacuum-oven (30° C.) for 18 hours

ORD-Eintrag

ord-940e23a02e854f58b114ccfb945c42d9

Quelldatensatz

uspto-grants-2006_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07012143B2