Hydrochloric Acid → Pentanol, 4-methyl-4-nitro-

Temperature

5 °C

Methyl 4-methyl-4-nitropentanoate (17.5 g, 0.1 mol) was dissolved in ethanol (200 ml) and cooled to 5° C., after which sodium borohydride (7.55 g, 0.2 mol) was added. The mixture was stirred at room temperature for 1 h, and at 50° C. for 3 h. Water (100 ml) and hydrochloric acid were added to adjust the pH to 3, and ethanol was evaporated by concentration under reduced pressure. The residue was extracted with ethyl acetate (250 ml) and water (100 ml) and washed with saturated brine. Ethyl acetate was evaporated by concentration under reduced pressure to give the objective compound (14.7 g, yield 91.2%).

1. waitat 50° C. for 3 h
2. customwas evaporated by concentration under reduced pressure
3. extractionThe residue was extracted with ethyl acetate (250 ml) and water (100 ml)
4. washwashed with saturated brine
5. customEthyl acetate was evaporated by concentration under reduced pressure

ORD record

ord-d63b88b4506b4ef68622ca524d0d8d27

Source dataset

uspto-grants-2006_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07012152B2