HRID1744109

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCN(c2ccc(B(O)O)cc2)CC1

HCID5233014

4-(4-BOC-Piperazino)phenylboronic acid

C15H23BN2O4

结构：Cc1onc(N[C@@H](CC(C)C)C(=O)NCC#N)c1Br

HCID86594565

未命名化合物

PRODUCTS

生成物

结构：Cc1onc(N[C@@H](CC(C)C)C(=O)NCC#N)c1-c1ccc(N2CCNCC2)cc1

HCID86594566

未命名化合物

PROCEDURE

实验过程

N2-(4-bromo-5-methylisoxazol-3-yl)-N1-(cyanomethyl)leucinamide was treated with 4-[4-(tert-butoxycarbonyl)-1-piperazinyl]phenylboronic acid (prepared as described in Example 1) as described in Example 1 to afford, after BOC removal with methanesulfonic acid as described in Example 1, N1-(cyanomethyl)-N2-[5-methyl-4-(4-piperazin-1-ylphenyl)isoxazol-3-yl]leucinamide. MS (+APCI): 411.4 [M+1]+

WORKUP

后处理

customto afford
customafter BOC removal with methanesulfonic acid