HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-BOC-Piperazino)phenylboronic acid → N1-(Cyanomethyl)-N2-[5-Methyl-4-(4-Piperazin-1-ylphenyl)Isoxazol-3-yl]Leucinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-BOC-Piperazino)phenylboronic acid | HCID 5233014 | — |
| Reactant | N2-(4-bromo-5-methylisoxazol-3-yl)-N1-(cyanomethyl)leucinamide | HCID 86594565 | — |
| Product | N1-(Cyanomethyl)-N2-[5-Methyl-4-(4-Piperazin-1-ylphenyl)Isoxazol-3-yl]Leucinamide | HCID 86594566 | — |
Reaction Steps
N2-(4-bromo-5-methylisoxazol-3-yl)-N1-(cyanomethyl)leucinamide was treated with 4-[4-(tert-butoxycarbonyl)-1-piperazinyl]phenylboronic acid (prepared as described in Example 1) as described in Example 1 to afford, after BOC removal with methanesulfonic acid as described in Example 1, N1-(cyanomethyl)-N2-[5-methyl-4-(4-piperazin-1-ylphenyl)isoxazol-3-yl]leucinamide. MS (+APCI): 411.4 [M+1]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012075B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-978bfb20187145bf8f53a5c25c86ba0e |
| Source note | uspto-grants-2006_03 |