Hydrochloric Acid → 246852-07-3

Participants

Reaction Conditions

Reaction Steps

12 ml of concentrated hydrochloride was dissolved in 100 ml of methanol, and 54 g of amlodipine prepared in Comparative Example 1 was dissolved in 500 ml of methanol and added dropwise to the solution of hydrochloride in methanol, followed by stirring at 23° C. for 3 hours. The resulting solid was filtered, washed with methanol (100 ml) and n-hexane (100 ml) and vacuum-dried.

Provenance & Evidence