Hydrochloric Acid → 246852-07-3

HRID 1744241Notes

Reaction equation

HRID 1744241 reaction equation
[ClH:1].[CH3:2][CH2:3][O:4][C:5]([C:7]1[CH:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=2[Cl:19])[C:11]([C:20]([O:22][CH3:23])=[O:21])=[C:10]([CH3:24])[NH:9][C:8]=1[CH2:25][O:26][CH2:27][CH2:28][NH2:29])=[O:6]>CO>[CH3:2][CH2:3][O:4][C:5]([C:7]1[CH:12]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:11]([C:20]([O:22][CH3:23])=[O:21])=[C:10]([CH3:24])[NH:9][C:8]=1[CH2:25][O:26][CH2:27][CH2:28][NH2:29])=[O:6].[ClH:1]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 2162Amlodipine

Product 1

HCID 22228524246852-07-3

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Conditions

Temperature
23 °C

Procedure

12 ml of concentrated hydrochloride was dissolved in 100 ml of methanol, and 54 g of amlodipine prepared in Comparative Example 1 was dissolved in 500 ml of methanol and added dropwise to the solution of hydrochloride in methanol, followed by stirring at 23° C. for 3 hours. The resulting solid was filtered, washed with methanol (100 ml) and n-hexane (100 ml) and vacuum-dried.

Workup

  1. filtrationThe resulting solid was filtered
  2. washwashed with methanol (100 ml) and n-hexane (100 ml)
  3. customvacuum-dried

Sources & evidence

ORD record
ord-6af06f203bd14f30a571b5d5f2f1d222
Source dataset
uspto-grants-2006_03
Patent number
US07015238B2

Reaction notes

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