Potassium hydroxy sulfite → HCID 86596517, compound

HRID 1744308Notes

Reaction equation

HRID 1744308 reaction equation
O[O:2][S:3]([O-:5])=O.[K+].[C:7]([O-])(O)=O.[Na+].O.[F:13][C:14]1[C:19]([O:20][CH3:21])=[CH:18][CH:17]=[CH:16][C:15]=1[C:22]1[C:23](=[O:50])[N:24]([CH2:40][C@@H:41]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH2:42][OH:43])[C:25](=[O:39])[N:26]([CH2:29][C:30]2[C:35](SC)=[CH:34][CH:33]=[CH:32][C:31]=2[F:38])[C:27]=1[CH3:28]>O.CC(C)=O>[F:13][C:14]1[C:19]([O:20][CH3:21])=[CH:18][CH:17]=[CH:16][C:15]=1[C:22]1[C:23](=[O:50])[N:24]([CH2:40][C@@H:41]([C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH2:42][OH:43])[C:25](=[O:39])[N:26]([CH2:29][C:30]2[C:35]([S:3]([CH3:7])(=[O:5])=[O:2])=[CH:34][CH:33]=[CH:32][C:31]=2[F:38])[C:27]=1[CH3:28]

Participants

6

Reactant 3

HCID 23707502Potassium hydroxy sulfiteHCID 86585896Sodium bicarbonate waterHCID 86596518HCID 86596518, compound

Product 1

HCID 86596517HCID 86596517, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

Oxone (4.61 g, 7.5 mmol) was dissolved in water (20 mL) and saturated NaHCO3/H2O was added until the mixture was basic. A solution of 8c (1.35 g, 2.5 mmol) in acetone (20 mL) was added and the reaction mixture was stirred at room temperature for 3 hr. The reaction mixture was filtered, and the filtrate was evaporated to give 8d (1.31 g, 92%). MS (CI) m/z 571.30 (MH+).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-7e0aea0bd28c446da229658c83940cfd
Source dataset
uspto-grants-2006_03
Patent number
US07015226B2

Reaction notes

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