反应详情

To compound 11c (300 mg, 0.5 mmol) in dichloromethane (2 mL) was added TFA (2 mL) and the reaction mixture was stirred at ambient temperature for 1 hour. Volatiles were evaporated and the residue was partitioned between saturated NaHCO3/water and EtOAc. The organic layer was dried (sodium sulfate), evaporated, purified by reverse phase HPLC (C-18 column, 15–75% ACN/water) to give compound 11d. MS (CI) m/z 502.2 (MH+).

1. customVolatiles were evaporated
2. customthe residue was partitioned between saturated NaHCO3/water and EtOAc
3. dry with materialThe organic layer was dried (sodium sulfate)
4. customevaporated
5. custompurified by reverse phase HPLC (C-18 column, 15–75% ACN/water)