HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178418973, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(1-Methylpiperidin-3-ylmethoxy)-phenylamine hydrochloride | HCID 69976959 | — |
| Reactant | 5-chloro-3-(hydroxymethylidene)-1H-indol-2-one | HCID 178419036 | — |
| Product | HCID 178418973 | HCID 178418973 | 49.3% |
Reaction Steps
In a manner similar to that described in Example 231, 4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine hydrochloride (158 mg, 1.2 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (100 mg, 0.51 mmol, 1 equiv.) with the addition of anhydrous Et3N (2.11 equiv.) are reacted to give the named compound as a yellow solid (100 mg, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015220B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-3de85a809da647e9b54e30c7f039c8a0 |
| Source note | uspto-grants-2006_03 |