Triethylamine → HCID 178418973, compound

HRID 1744375Notes

Reaction equation

HRID 1744375 reaction equation
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH2:4]1.[Cl:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[C:22]2=[CH:29]O.CCN(CC)CC>>[Cl:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[C:22]2=[CH:29][NH:17][C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][N:3]([CH3:2])[CH2:4]2)=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 699769594-(1-Methylpiperidin-3-ylmethoxy)-phenylamine hydrochlorideHCID 1784190365-chloro-3-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178418973HCID 178418973, compoundYield 49.3%

Procedure

In a manner similar to that described in Example 231, 4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine hydrochloride (158 mg, 1.2 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (100 mg, 0.51 mmol, 1 equiv.) with the addition of anhydrous Et3N (2.11 equiv.) are reacted to give the named compound as a yellow solid (100 mg, 49%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-3de85a809da647e9b54e30c7f039c8a0
Source dataset
uspto-grants-2006_03
Patent number
US07015220B2

Reaction notes

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