反应详情

1.69 kg (9.51 moles) of NBS and 156 g (0.95 moles) of AIBN were well mixed and placed in a vinyl wrapper (at this time, the previous reaction was regarded to be proceeded to 100%). The benzene solution of Example 2 was heated. The NBS-AIBN mixture was portionwise added to the heated solution at 73° C. for 40 minutes. The solution was refluxed for 1.5 hours after the addition was done. After confirming completion of the reaction by HPLC, the solution was cooled to room temperature. The reaction solution was washed with [1 L of H2O+4 L of 5% NaHCO3], and then [2 L of H2O+1 L of 5% NaCl].

1. customthe previous reaction
2. temperatureThe solution was refluxed for 1.5 hours
3. additionafter the addition
4. customcompletion of the reaction by HPLC
5. washThe reaction solution was washed with [1 L of H2O+4 L of 5% NaHCO3]