反应详情

A solution of the compound obtained in Example 1, Step f (40 mg) in ethanol (2 ml) was added with 1 N aqueous sodium hydroxide (0.1 ml) and stirred at room temperature for 2 hours and then at 50° C. for 1 hour. The reaction mixture was added with 1 N hydrochloric acid (0.1 ml) and concentrated, and the resulting residue was applied on a silica gel column and eluted with methylene chloride/ethanol (10:1, containing 1% acetic acid) to obtain the title compound (35.6 mg).

1. waitat 50° C. for 1 hour
2. concentrationconcentrated
3. washeluted with methylene chloride/ethanol (10:1, containing 1% acetic acid)