反应详情

2-Chloro-5-nitrobenzonitrile (20 g) and piperidine (9.34 g) were added to ethanol (100 ml) and the mixture was stirred at a refluxing temperature for 1 h. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the residue to allow crystallization. The crystals were recrystallized from hydrous ethanol to give 5-nitro-2-piperidinobenzonitrile (17 g), melting point 75° C.

1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
2. additionwas added to the residue
3. customcrystallization
4. customThe crystals were recrystallized from hydrous ethanol