Diethylamine → HCID 12902435, compound

HRID 1744503Notes

Reaction equation

HRID 1744503 reaction equation
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>C(O)C>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[C:3]([CH:6]=1)[C:4]#[N:5])([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 855042-Chloro-5-nitrobenzonitrile

Product 1

HCID 12902435HCID 12902435, compoundYield 86.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Chloro-5-nitrobenzonitrile (15 g) and diethylamine (15 g) were added to ethanol (100 ml) and the mixture was stirred at a refluxing temperature for 1 h. The solvent was evaporated under reduced pressure. Diisopropyl ether was added to the residue to allow crystallization. The crystals were recrystallized from hydrous ethanol to give 5-nitro-2-diethylaminobenzonitrile (15.6 g), melting point: 98° C.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionDiisopropyl ether was added to the residue
  3. customcrystallization
  4. customThe crystals were recrystallized from hydrous ethanol

Sources & evidence

ORD record
ord-2c07d24ae0a14497a2220c61f70c1702
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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