Hydrochloric Acid → 5-Nitro-2-(4-oxopiperidin-1-yl)benzonitrile

HRID 1744534ノート

反応式

HRID 1744534 の反応式
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].Cl.O.[NH:15]1[CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]1.C(N(CC)CC)C.Cl>C(#N)C>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([N:15]2[CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]2)=[C:3]([CH:6]=1)[C:4]#[N:5])([O-:12])=[O:11]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 855042-Chloro-5-nitrobenzonitrileHCID 2723901Piperonylamine

生成物 1

HCID 222279875-Nitro-2-(4-oxopiperidin-1-yl)benzonitrile収率 79.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-Chloro-5-nitrobenzonitrile (15 g), 4-piperidone monohydrate hydrochloride (13.9 g) and triethylamine (25 ml) were added to acetonitrile (100 ml), and the mixture was stirred at a refluxing temperature for 1.5 h. 0.5 N Aqueous hydrochloric acid solution (200 ml) was added to the reaction mixture to allow crystallization to give the title compound (16.1 g), melting point: 109° C.

後処理

  1. customcrystallization

出典と根拠

ORDレコード
ord-1aceaba6d95e4aebb59e834c4eaf6878
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

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