2-(Methylamino)ethanol → 5-Amino-2-[4-(N-2-hydroxyethyl-N-methylamino)piperidin-1-yl]benzonitrile

HRID 1744536ノート

反応式

HRID 1744536 の反応式
[N+](C1C=CC(N2CCC(=O)CC2)=C(C=1)C#N)([O-])=O.CNCCO.[OH:24][CH2:25][CH2:26][N:27]([CH:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:42]=[CH:41][C:40]([N+:43]([O-])=O)=[CH:39][C:36]=2[C:37]#[N:38])[CH2:31][CH2:30]1)[CH3:28]>>[NH2:43][C:40]1[CH:41]=[CH:42][C:35]([N:32]2[CH2:33][CH2:34][CH:29]([N:27]([CH2:26][CH2:25][OH:24])[CH3:28])[CH2:30][CH2:31]2)=[C:36]([CH:39]=1)[C:37]#[N:38]

参加物

4

反応物 3

HCID 80162-(Methylamino)ethanolHCID 178227712-[4-(N-2-hydroxyethyl-N-methylamino) piperidin-1-yl]-5-nitrobenzonitrileHCID 222279875-Nitro-2-(4-oxopiperidin-1-yl)benzonitrile

生成物 1

HCID 222280815-Amino-2-[4-(N-2-hydroxyethyl-N-methylamino)piperidin-1-yl]benzonitrile

実験手順

According to Tetrahedron, vol. 38, No. 3, p. 413 (1982) and using 5-nitro-2-(4-oxopiperidino) benzonitrile and N-methylethanolamine, 2-[4-(N-2-hydroxyethyl-N-methylamino) piperidin-1-yl]-5-nitrobenzonitrile was synthesized, which was subjected to reduction according to Starting Material Synthesis Example 40 to give the title compound.

後処理

  1. customwas synthesized
  2. customaccording to Starting Material Synthesis Example 40

出典と根拠

ORDレコード
ord-502ca6b34eec414f990b9f98603c3533
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

読み込み中…