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2-(Methylamino)ethanol → 5-Amino-2-[4-(N-2-hydroxyethyl-N-methylamino)piperidin-1-yl]benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methylamino)ethanol | HCID 8016 | — |
| 反応物 | 2-[4-(N-2-hydroxyethyl-N-methylamino) piperidin-1-yl]-5-nitrobenzonitrile | HCID 17822771 | — |
| 反応物 | 5-Nitro-2-(4-oxopiperidin-1-yl)benzonitrile | HCID 22227987 | — |
| 生成物 | 5-Amino-2-[4-(N-2-hydroxyethyl-N-methylamino)piperidin-1-yl]benzonitrile | HCID 22228081 | — |
反応手順
According to Tetrahedron, vol. 38, No. 3, p. 413 (1982) and using 5-nitro-2-(4-oxopiperidino) benzonitrile and N-methylethanolamine, 2-[4-(N-2-hydroxyethyl-N-methylamino) piperidin-1-yl]-5-nitrobenzonitrile was synthesized, which was subjected to reduction according to Starting Material Synthesis Example 40 to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07015218B1 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-502ca6b34eec414f990b9f98603c3533 |
| 出典メモ | uspto-grants-2006_03 |