2-Methoxyethylamine → 5-Amino-2-[4-[N-tert-butoxycarbonyl-N-(2-methoxyethyl)amino]piperidin-1-yl]benzonitrile

HRID 1744540Notes

Reaction equation

HRID 1744540 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:17][CH2:18][OH:19])[CH2:12][CH2:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[N+]([C:30]1C=CC(N2CCC(=O)CC2)=C(C=1)C#N)([O-])=O.COCCN>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:17][CH2:18][O:19][CH3:30])[CH2:12][CH2:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 222279875-Nitro-2-(4-oxopiperidin-1-yl)benzonitrileHCID 222280265-amino-2-[4-(N-tert-butoxycarbonyl-2-hydroxyethylamino)piperidin-1-yl]benzonitrile

Product 1

HCID 222281555-Amino-2-[4-[N-tert-butoxycarbonyl-N-(2-methoxyethyl)amino]piperidin-1-yl]benzonitrile

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 85(2), (3) and (4) using 5-nitro-2-(4-oxopiperidino)benzonitrile and 2-methoxyethylamine, the title compound as obtained.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-5595c420cd024dcf9ad3658f63f38408
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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