2-Hydrazinopyridine → 5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

HRID 1744541Notes

Reaction equation

HRID 1744541 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][NH2:8].C(O[CH:12]=[C:13]([C:19]([CH3:21])=O)[C:14]([O:16]CC)=[O:15])C>>[CH3:21][C:19]1[N:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[N:8]=[CH:12][C:13]=1[C:14]([OH:16])=[O:15]

Participants

3

Reactant 2

HCID 786452-HydrazinopyridineHCID 97734Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester

Product 1

HCID 167776245-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acidYield 63.1%

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 1 using 2-pyridylhydrazine (8.0 g) and ethyl 2-ethoxymethyleneacetoacetate (13.7 g), the title compound (9.4 g) was obtained, melting point: 165° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-2ef67f870bff4383a39557e6c01db013
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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