2-Chloro-5-nitrobenzotrifluoride → 4-(4-Morpholinopiperidin-1-yl)-3-trifluoromethylaniline

HRID 1744548Notes

Reaction equation

HRID 1744548 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[O:15]1[CH2:20][CH2:19][N:18]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH2:17][CH2:16]1>>[O:15]1[CH2:16][CH2:17][N:18]([CH:21]2[CH2:26][CH2:25][N:24]([C:2]3[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=3[C:11]([F:14])([F:13])[F:12])[CH2:23][CH2:22]2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 612132-Chloro-5-nitrobenzotrifluorideHCID 7957244-Morpholinopiperidine

Product 1

HCID 222279174-(4-Morpholinopiperidin-1-yl)-3-trifluoromethylaniline

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 40 using 4-chloro-3-trifluoromethylnitrobenzene and 4-morpholinopiperidine, the title compound was obtained, melting point: 118–120° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-bfc87880b6024ba68ba3b771435ca774
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

Loading…