Chloromethyl Methyl Ether → HCID 22228130, compound

HRID 1744549Notes

Reaction equation

HRID 1744549 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[CH3:17][O:18][CH2:19]Cl>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:17][O:18][CH3:19])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 7864Chloromethyl Methyl EtherHCID 24758Sodium hydrideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 22228130HCID 22228130, compound

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 59 using N-(tert-butoxycarbonyl)-4-hydroxypiperidine, sodium hydride and methoxymethylchloride, N-(tert-butoxycarbonyl)-4-methoxymethoxypiperidine was obtained. This was treated with trifluoroacetic acid-chloroform to give 4-methoxymethoxypiperidine, which was subjected to the reaction and treatment in the same manner as in Starting Material Synthesis Example 40 using 4-fold equivalents of triethylamine to give the title compound.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-cb101d7beae64f3aa5caa48f84a993aa
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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