HRID1744633

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22227997

未命名化合物

HCID22228086

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)Nc2ccc(N3CCC(N4CCOCC4)CC3)cc2C#N)cnn1-c1ccc(C(F)(F)F)cc1

HCID22228003

未命名化合物

收率 39.9%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (0.9 g) and 2-amino-5-(4-morpholinopiperidin-1-yl)benzonitrile (0.9 g), the title compound (0.67 g) was obtained, melting point: 210–212° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d247a9990724c99899a54fd267f7176
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07015218B1
来源说明: uspto-grants-2006_03

反应 SMILES

[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[NH2:20][C:21]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][CH:32]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[CH2:31][CH2:30]2)=[CH:25][C:22]=1[C:23]#[N:24]>>[C:23]([C:22]1[CH:25]=[C:26]([N:29]2[CH2:34][CH2:33][CH:32]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[CH2:31][CH2:30]2)[CH:27]=[CH:28][C:21]=1[NH:20][C:17]([C:3]1[CH:4]=[N:5][N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[C:2]=1[CH3:1])=[O:18])#[N:24]