2-Amino-5-(4-morpholinopiperidin-1-yl)benzonitrile → N-[2-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide

HRID 1744633Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744633
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[NH2:20][C:21]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][CH:32]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[CH2:31][CH2:30]2)=[CH:25][C:22]=1[C:23]#[N:24]>>[C:23]([C:22]1[CH:25]=[C:26]([N:29]2[CH2:34][CH2:33][CH:32]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[CH2:31][CH2:30]2)[CH:27]=[CH:28][C:21]=1[NH:20][C:17]([C:3]1[CH:4]=[N:5][N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[C:2]=1[CH3:1])=[O:18])#[N:24]

Komponenten

3

Edukt 2

HCID 222279972-Amino-5-(4-morpholinopiperidin-1-yl)benzonitrileHCID 222280865-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride

Produkt 1

HCID 22228003N-[2-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamideAusbeute 39,9 %

Versuchsvorschrift

By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (0.9 g) and 2-amino-5-(4-morpholinopiperidin-1-yl)benzonitrile (0.9 g), the title compound (0.67 g) was obtained, melting point: 210–212° C.

Quellen und Nachweise

ORD-Eintrag
ord-3d247a9990724c99899a54fd267f7176
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07015218B1

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