HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(4-morpholinopiperidin-1-yl)benzonitrile → N-[2-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 22227997 | — |
| Reactant | 5-Methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride | HCID 22228086 | — |
| Product | N-[2-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxamide | HCID 22228003 | 39.9% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 150 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic chloride (0.9 g) and 2-amino-5-(4-morpholinopiperidin-1-yl)benzonitrile (0.9 g), the title compound (0.67 g) was obtained, melting point: 210–212° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-3d247a9990724c99899a54fd267f7176 |
| Source note | uspto-grants-2006_03 |