1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → 1-(4-Chlorophenyl)-N-[3-chloro-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide

HRID 1744638Notes

Reaction equation

HRID 1744638 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][C:24]=1[N:25]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[CH2:27][CH2:26]1)[NH2:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:21][C:20]3[CH:22]=[CH:23][C:24]([N:25]4[CH2:30][CH2:29][CH:28]([N:31]5[CH2:36][CH2:35][O:34][CH2:33][CH2:32]5)[CH2:27][CH2:26]4)=[C:18]([Cl:17])[CH:19]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 222281773-Chloro-4-(4-morpholinopiperidin-1-yl)aniline

Product 1

HCID 222282011-(4-Chlorophenyl)-N-[3-chloro-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamideYield 42.1%

Procedure

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.6 g) and 3-chloro-4-(4-morpholinopiperidin-1-yl)aniline (0.7 g), the title compound (0.51 g) was obtained, melting point: 238–240° C.

Sources & evidence

ORD record
ord-49c334054001403a92ee0023433a6c38
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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