HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → 1-(4-Chlorophenyl)-N-[3-chloro-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride | HCID 2776128 | — |
| Reactant | 3-Chloro-4-(4-morpholinopiperidin-1-yl)aniline | HCID 22228177 | — |
| Product | 1-(4-Chlorophenyl)-N-[3-chloro-4-(4-morpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide | HCID 22228201 | 42.1% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.6 g) and 3-chloro-4-(4-morpholinopiperidin-1-yl)aniline (0.7 g), the title compound (0.51 g) was obtained, melting point: 238–240° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-49c334054001403a92ee0023433a6c38 |
| Source note | uspto-grants-2006_03 |