HRID1744644

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10778429

未命名化合物

HCID21942323

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)Nc2ccc(N3CCN(C4CCOCC4)CC3)c(C#N)c2)cnn1-c1ccc(C(F)(F)F)cc1

HCID22228000

未命名化合物

收率 48.3%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 64 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic acid (1.1 g) and 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile (1.1 g), the title compound (1.0 g) was obtained, melting point: 274° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2e1230cb77834bfd9cffd7ef612672ac
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07015218B1
来源说明: uspto-grants-2006_03

反应 SMILES

[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](O)=[O:18].[NH2:20][C:21]1[CH:22]=[CH:23][C:24]([N:29]2[CH2:34][CH2:33][N:32]([CH:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[CH2:31][CH2:30]2)=[C:25]([CH:28]=1)[C:26]#[N:27]>>[C:26]([C:25]1[CH:28]=[C:21]([NH:20][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:8]=[CH:9][C:10]([C:13]([F:15])([F:16])[F:14])=[CH:11][CH:12]=3)[C:2]=2[CH3:1])=[O:18])[CH:22]=[CH:23][C:24]=1[N:29]1[CH2:34][CH2:33][N:32]([CH:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)[CH2:31][CH2:30]1)#[N:27]