5-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid → N-{3-Cyano-4-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}-5-methyl-1-(4-trifluoromethylphenyl)pyrazole 4-carboxamide
Reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:17](O)=[O:18].[NH2:20][C:21]1[CH:22]=[CH:23][C:24]([N:29]2[CH2:34][CH2:33][N:32]([CH:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[CH2:31][CH2:30]2)=[C:25]([CH:28]=1)[C:26]#[N:27]>>[C:26]([C:25]1[CH:28]=[C:21]([NH:20][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:8]=[CH:9][C:10]([C:13]([F:15])([F:16])[F:14])=[CH:11][CH:12]=3)[C:2]=2[CH3:1])=[O:18])[CH:22]=[CH:23][C:24]=1[N:29]1[CH2:34][CH2:33][N:32]([CH:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)[CH2:31][CH2:30]1)#[N:27]Participants
3
Reactant 2
Product 1
Procedure
By the reaction and treatment in the same manner as in Example 64 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic acid (1.1 g) and 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile (1.1 g), the title compound (1.0 g) was obtained, melting point: 274° C.
Sources & evidence
- ORD record
- ord-2e1230cb77834bfd9cffd7ef612672ac
- Source dataset
- uspto-grants-2006_03
- Patent number
- US07015218B1
Reaction notes
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