5-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid → N-{3-Cyano-4-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}-5-methyl-1-(4-trifluoromethylphenyl)pyrazole 4-carboxamide

Participants

Reaction Steps

By the reaction and treatment in the same manner as in Example 64 using 5-methyl-1-(4-trifluoromethylphenyl)pyrazole-4-carboxylic acid (1.1 g) and 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile (1.1 g), the title compound (1.0 g) was obtained, melting point: 274° C.

Provenance & Evidence