1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(2-methoxyethylamino)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide

HRID 1744648Notes

Reaction equation

HRID 1744648 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32](C(OC(C)(C)C)=O)[CH2:33][CH2:34][O:35][CH3:36])[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([N:26]4[CH2:31][CH2:30][CH:29]([NH:32][CH2:33][CH2:34][O:35][CH3:36])[CH2:28][CH2:27]4)=[C:22]([C:23]#[N:24])[CH:25]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 222281555-Amino-2-[4-[N-tert-butoxycarbonyl-N-(2-methoxyethyl)amino]piperidin-1-yl]benzonitrile

Product 1

HCID 222282191-(4-Chlorophenyl)-N-{3-cyano-4-[4-(2-methoxyethylamino)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamideYield 51.7%

Procedure

By the reaction and treatment in the same manner as in Example 151 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.6 g) and 5-amino-2-[4-[N-tert-butoxycarbonyl-N-(2-methoxyethyl) amino]piperidin-1-yl]benzonitrile (0.9 g), the title compound (0.6 g) was obtained, melting point: 194° C.

Sources & evidence

ORD record
ord-d4a5f642d1e643bca47ca3af97899c1a
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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