5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid → N-[3-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(2-pyridyl)pyrazole-4-carboxamide
反応式
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:13]([OH:15])=O.[NH2:16][C:17]1[CH:18]=[CH:19][C:20]([N:25]2[CH2:30][CH2:29][CH:28]([N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[CH2:27][CH2:26]2)=[C:21]([CH:24]=1)[C:22]#[N:23]>>[C:22]([C:21]1[CH:24]=[C:17]([NH:16][C:13]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)[C:2]=2[CH3:1])=[O:15])[CH:18]=[CH:19][C:20]=1[N:25]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[CH2:27][CH2:26]1)#[N:23]参加物
3
実験手順
By the reaction and treatment in the same manner as in Example 64 using 5-methyl-1-(2-pyridyl)pyrazole-4-carboxylic acid (2.0 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (1.88 g), the title compound (1.52 g) was obtained, melting point: 251° C.
出典と根拠
- ORDレコード
- ord-79ada18d9d0440b8bdc4953688e11625
- 出典データセット
- uspto-grants-2006_03
- 特許番号
- US07015218B1
反応ノート
読み込み中…