HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid → N-[3-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(2-pyridyl)pyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid | HCID 16777624 | — |
| Reactant | 5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 21942389 | — |
| Product | N-[3-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methyl-1-(2-pyridyl)pyrazole-4-carboxamide | HCID 22227899 | 49.1% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 64 using 5-methyl-1-(2-pyridyl)pyrazole-4-carboxylic acid (2.0 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (1.88 g), the title compound (1.52 g) was obtained, melting point: 251° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-79ada18d9d0440b8bdc4953688e11625 |
| Source note | uspto-grants-2006_03 |