Trifluoroacetic acid → HCID 22225221, compound

HRID 1744803Notes

Reaction equation

HRID 1744803 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:37]=[CH:36][C:9]([NH:10][C:11]2[N:12]=[C:13]([CH3:35])[C:14]3[CH:20]=[CH:19][C:18](=[O:21])[N:17]([C:22]4[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[CH:24][CH:23]=4)[C:15]=3[N:16]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([NH:10][C:11]2[N:12]=[C:13]([CH3:35])[C:14]3[CH:20]=[CH:19][C:18](=[O:21])[N:17]([C:22]4[CH:23]=[CH:24][C:25]([C:26]([OH:28])=[O:27])=[CH:33][CH:34]=4)[C:15]=3[N:16]=2)=[CH:36][CH:37]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22225233HCID 22225233, compound

Product 1

HCID 22225221HCID 22225221, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of compound 3 (0.12 g; 0.2397 mmol) and trifluoroacetic acid (0.2 mL; 2.62 mmol) in 3 mL of methylene chloride was stirred at room temperature for 2 h. The reaction mixture was concentrated and the crude product taken up with ethyl acetate and n-hexane to yield compound 9 (0.09 g; 84%).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-5581bac313df4336bc2338cdd13bd4e1
Source dataset
uspto-grants-2006_03
Patent number
US07019002B2

Reaction notes

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