Hydrochloric Acid → HCID 9808299, compound

HRID 1744829Notes

Reaction equation

HRID 1744829 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:37])[CH2:5][CH2:6][C:7]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24]([C:27]4[C:31]5[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=5[S:29][N:28]=4)[CH2:23][CH2:22]3)=[C:15]([Cl:18])[CH:16]=2)[CH2:11][C:10]1=[O:36])=[O:8].[CH2:38](O)C.Cl>O>[ClH:18].[CH2:2]([O:3][C:4](=[O:37])[CH2:5][CH2:6][C:7]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24]([C:27]4[C:31]5[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=5[S:29][N:28]=4)[CH2:23][CH2:22]3)=[C:15]([Cl:18])[CH:16]=2)[CH2:11][C:10]1=[O:36])=[O:8])[CH3:38]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 131725391HCID 131725391, compound

Product 1

HCID 9808299HCID 9808299, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product of Example 5, (611 mg, 1.1 mmol) was mixed with ethanol (27 mL) and concentrated hydrochloric acid (0.5 mL) and the mixture boiled under reflux for 24 h in the temperature range 78-80° C. Distilled water (20 mL) was added to the hot reaction mixture and solids removed during the hot filtration. The filtrate was cooled further and product solids were isolated by filtration, washed with distilled water (20 mL), and dried under vacuum to yield 200 mg (32%).

Workup

  1. temperatureunder reflux for 24 h in the temperature
  2. customrange 78-80° C
  3. customremoved during the hot filtration
  4. temperatureThe filtrate was cooled further
  5. customproduct solids were isolated by filtration
  6. washwashed with distilled water (20 mL)
  7. customdried under vacuum
  8. customto yield 200 mg (32%)

Sources & evidence

ORD record
ord-819d2298957f449883c03c4ac753f127
Source dataset
uspto-grants-2006_03
Patent number
US07019009B2

Reaction notes

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