HCID 11172083, compound → HCID 11229736, compound

HRID 1744954Notes

Reaction equation

HRID 1744954 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]3[CH:11]=[C:10]([CH2:12][OH:13])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1>C(Cl)Cl.CN(C=O)C.O=[Mn]=O>[CH:12]([C:10]1[N:9]=[C:7]2[N:6]([CH:11]=1)[C:5]1[CH:14]=[CH:15][C:2]([F:1])=[CH:3][C:4]=1[S:8]2)=[O:13]

Participants

4

Reactant 1

HCID 11172083HCID 11172083, compound

Product 1

HCID 11229736HCID 11229736, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideSolventHCID 22350042dichloromethane N,N-dimethylformamideSolvent

Procedure

2-Formyl-7-fluoro-imidazo[2,1-b]-benzthiazole was prepared according to the procedure outlined in Example 1, (Step 3). Starting from 7-fluoro-imidazo[2,1-b]-benzthiazole-2-methanol (1.5 g 6.7 mmol) in methylene chloride/DMF(300 mL: 50 mL) and active MnO2 (12 g, excess), 1.1 g (78% Yield) of the aldehyde derivative was isolated as brown solid. (M+H) 221.

Workup

  1. customwas isolated as brown solid

Sources & evidence

ORD record
ord-7b1f9987bf404ed99f2a8e4ed70ad456
Source dataset
uspto-grants-2006_03
Patent number
US07018997B2

Reaction notes

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