1-Naphthalenemethanamine → HCID 69250302, compound

HRID 1745069Notes

Reaction equation

HRID 1745069 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[C:17]1([CH:23]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)C(Cl)=O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[C:33]1([CH2:43][NH2:44])[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1>>[C:27]1([CH:23]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:6]([N:8]2[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]2[C:10]([NH:44][CH2:43][C:33]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH:36]=[CH:35][CH:34]=2)=[O:12])=[O:7])[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 83551-NaphthalenemethanamineHCID 746372,2-Diphenylacetyl chlorideHCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

Product 1

HCID 69250302HCID 69250302, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-oxoproline, diphenylacetyl chloride, and 1-naphthylmethylamine the title com-pound was obtained in 60% purity by LC/MS. MS(ESI+): m/z=463.4.

Workup

  1. customwas obtained in 60% purity by LC/MS

Sources & evidence

ORD record
ord-e863715f7b784ab584f7a1ce1b377c4f
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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