N,N-Diethylethylenediamine → HCID 69250323, compound

HRID 1745079Notes

Reaction equation

HRID 1745079 reaction equation
[CH:1](=[C:8]1[CH2:12][N:11]([C:13]([O:15]C(C)(C)C)=O)[C@H:10]([C:20]([OH:22])=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:23]1([CH:29]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)C(Cl)=O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[CH2:39]([N:41]([CH2:45][CH3:46])[CH2:42][CH2:43][NH2:44])[CH3:40]>>[CH:1](=[C:8]1[CH2:12][N:11]([C:13](=[O:15])[CH:29]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C@H:10]([C:20]([NH:44][CH2:43][CH2:42][N:41]([CH2:45][CH3:46])[CH2:39][CH3:40])=[O:22])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 60993N,N-DiethylethylenediamineHCID 746372,2-Diphenylacetyl chlorideHCID 69250545(2S,4EZ)-4benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 69250323HCID 69250323, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzylidene-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and N1,N1-diethyl-1,2-ethanediamine the title compound was obtained in 71% purity by LC/MS. MS(ESI+): m/z=496.4.

Sources & evidence

ORD record
ord-1393719cbbd248878f17a3c433fb7dd1
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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