(2-Thienylmethyl)amine → HCID 131725458, compound

HRID 1745084Notes

Reaction equation

HRID 1745084 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([CH:25]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)C(Cl)=O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[S:35]1[CH:39]=[CH:38][CH:37]=[C:36]1[CH2:40][NH2:41]>>[C:29]1([CH:25]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]2[C:16]([NH:41][CH2:40][C:36]2[S:35][CH:39]=[CH:38][CH:37]=2)=[O:18])=[O:7])[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

4

Reactant 3

HCID 34005(2-Thienylmethyl)amineHCID 746372,2-Diphenylacetyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725458HCID 131725458, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2-thienylmethylamine the title compound was obtained in 88% purity by LC/MS. MS(ESI+): m/z=448.4.

Sources & evidence

ORD record
ord-3f9954d89aba438f84e0b0cda708eb78
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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