Furfurylamine → HCID 69250451, compound

HRID 1745104Notes

Reaction equation

HRID 1745104 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[C:17]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:22]=[CH:21][C:20](C(Cl)=O)=[CH:19][CH:18]=1.[O:32]1[CH:36]=[CH:35][CH:34]=[C:33]1[CH2:37][NH2:38]>>[C:26]1([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:27]=[CH:28][C:29]([C:6]([N:8]2[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]2[C:10]([NH:38][CH2:37][C:33]2[O:32][CH:36]=[CH:35][CH:34]=2)=[O:12])=[O:7])=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 3438FurfurylamineHCID 841514-Phenylbenzoyl chlorideHCID 21727417(2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid

Product 1

HCID 69250451HCID 69250451, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-methyleneproline, [1,1′-biphenyl]-4-carbonyl chloride, and 2-furylmethylamine the title compound was obtained in 94% purity by LC/MS. MS(ESI+): m/z=387.2.

Sources & evidence

ORD record
ord-6d06a845acf949c6a7881357c8f71453
Source dataset
uspto-grants-2006_03
Patent number
US07018988B2

Reaction notes

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