HRID1745121

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8588

3-Amino-9-ethylcarbazole

C14H14N2

HCID74193

Benzoyl chloride, 4-phenoxy-

C13H9ClO2

结构：CC(C)(C)OC(=O)N1CC(=CC#N)C[C@H]1C(=O)O

HCID69250314

未命名化合物

PRODUCTS

生成物

结构：CCn1c2ccccc2c2cc(NC(=O)[C@@H]3CC(=CC#N)CN3C(=O)c3ccc(Oc4ccccc4)cc3)ccc21

HCID69250533

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chlo-ride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 37% purity by LC/MS. MS(ESI+): m/z=541.4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a94edf5b618a47e1bfdaeee37fd5bbb7
来源数据集: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07018988B2
来源说明: uspto-grants-2006_03

反应 SMILES

C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[O:19]([C:26]1[CH:34]=[CH:33][C:29](C(Cl)=O)=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH2:35]([N:37]1[C:49]2[CH:48]=[CH:47][C:46]([NH2:50])=[CH:45][C:44]=2[C:43]2[C:38]1=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH3:36]>>[C:14]([CH:13]=[C:11]1[CH2:12][N:8]([C:6](=[O:7])[C:29]2[CH:28]=[CH:27][C:26]([O:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:34][CH:33]=2)[C@H:9]([C:16]([NH:50][C:46]2[CH:47]=[CH:48][C:49]3[N:37]([CH2:35][CH3:36])[C:38]4[C:43]([C:44]=3[CH:45]=2)=[CH:42][CH:41]=[CH:40][CH:39]=4)=[O:18])[CH2:10]1)#[N:15]