Water → tert-Butyl {4-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]pyrid-2-yl}carbamate

HRID 174517Notes

Reaction equation

HRID 174517 reaction equation
[C:24](=[O:25])([O-:26])[O-:27].[CH3:30][C:31]1([CH3:32])[C:33]([CH3:34])([CH3:35])[O:36][B:37]([c:38]2[cH:39][c:40]([NH:44][C:45]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:51])[n:41][cH:42][cH:43]2)[O:52]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([I:18])[c:9](-[c:11]1[cH:12][cH:13][c:14]([Cl:17])[cH:15][cH:16]1)[n:10]2.[Cs+:28].[Cs+:29].[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1.[OH2:53]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8](-[c:38]1[cH:39][c:40]([NH:44][C:45]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:51])[n:41][cH:42][cH:43]1)[c:9](-[c:11]1[cH:12][cH:13][c:14]([Cl:17])[cH:15][cH:16]1)[n:10]2

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 49760449tert-butyl N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamateHCID 594069676-Chloro-2-(4-chlorophenyl)-3-iodoimidazo[1,2-b]pyridazine

Product 1

HCID 59406969tert-Butyl {4-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]pyrid-2-yl}carbamate

Sources & evidence

ORD record
ord-236e69cd93364b3d8cd73d0754362050
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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